학술논문
Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs.
Document Type
Article
Author
Martínez-Domínguez, Samuel J.; García-Mateo, Sandra; Sainz-Arnal, Pilar; Martínez-García, Javier; Gallego-Llera, Beatriz; Lozano-Limones, María Jesús; Hidalgo, Sandra; Gargallo-Puyuelo, Carla J.; Latre-Santos, Marta; Nocito-Colon, Maria Mercedes Lourdes; Martínez-Lostao, Luis; Refaie, Engy; Arroyo-Villarino, Maria Teresa; del Rio-Nechaevsky, Marcela; Ramirez-Labrada, Ariel; Pardo, Julián; Gomollón, Fernando; Baptista, Pedro M.
Source
Subject
Language
ISSN
2045-2322
Abstract
Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy. [ABSTRACT FROM AUTHOR]