부산대학교 도서관

Background: Degeneration of the intervertebral disc (IVD), resulting from various factors, including genetic and environmental causes, is a significant musculoskeletal disorder. It is characterized by a gradual deterioration of the structure and a weakening in the function of the IVD, leading to a decline in the quality of life (QOL) or disability. Aim of the study: This study aimed to perform a review of scientific reports and a summary of the current knowledge regarding IVD degeneration in terms of etiopathogenesis, clinical symptoms, and various diagnostic methods. Materials and methods: The literature review was performed by searching key medical databases such as pubmed, MEDLINE, and Scopus. A search strategy was defined, encompassing keywords, synonyms, and controlled keywords (MeSH terms). The search included the last 20 years and focused on aspects of etiopathogenesis, clinical symptoms, and diagnostic methods. papers meeting the inclusion criteria underwent a full-text analysis. Data and information gathered from the literature analysis were synthesized to provide a comprehensive overview of the current state of knowledge on the researched subject. Results: The process of IVD degeneration is extremely complex, involving biochemical, metabolic, and morphological changes that impact its structure and function. It entails a gradual loss of water in the nucleus pulposus (dehydration), resulting in an impaired shock-absorbing function and leading to the formation of breaks in the annulus fibrosus, allowing herniation of the nucleus pulposus. for years, mechanical injuries, especially work-related injuries, have been considered the primary factors causing IVD degeneration. Recent findings emphasize the significant role of genetic factors, with the identification of several genes encoding structural proteins of the IVD. mutations in these genes may accelerate degeneration. Current clinical research results indicate a correlation between aortic calcifications and episodes of low back pain (LBP) and between lumbar artery stenosis, IVD degeneration, and subsequent LBP. Conclusions: understanding the complexity of IVD degeneration and its neurological consequences is crucial in planning effective treatment. It is essential to monitor the latest research to systematically update the etioknowledge and practical guidelines in the discussed area. Collaboration between an experienced neurosurgeon and an interdisciplinary team of medical specialists can achieve the best therapeutic outcomes. [ABSTRACT FROM AUTHOR]