학술논문
Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates.
Document Type
Article
Author
Source
Subject
*ANTIGEN analysis
*ARGININE
*BIRTH size
*STATISTICAL correlation
*DIETARY supplements
*FECES
*T-test (Statistics)
*RANDOMIZED controlled trials
*REPEATED measures design
*BLIND experiment
*DATA analysis software
*THERAPEUTICS
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Language
ISSN
0743-8346
Abstract
Objective:The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels.Study Design:The study enrolled 83 VLBW neonates with birth weight 1500 g and gestational age 34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5 mmol kg−1 per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay.Result:Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28.Conclusion:Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation. [ABSTRACT FROM AUTHOR]