학술논문
Gata3 Immunohistochemical Staining is A Useful Marker for Metastatic Breast Carcinoma in Fine Needle Aspiration Specimens.
Document Type
Article
Source
Subject
*BREAST cancer diagnosis
*BREAST tumor diagnosis
*CANCER diagnosis
*METASTASIS
*DUCTAL carcinoma
*ADENOCARCINOMA
*BONES
*BREAST tumors
*ESTROGEN receptors
*IMMUNOHISTOCHEMISTRY
*LIVER
*LYMPH nodes
*MELANOMA
*NEEDLE biopsy
*PELVIS
*STAINS & staining (Microscopy)
*THYROID gland tumors
*TRANSCRIPTION factors
*TUMOR markers
*DIAGNOSIS
GENITOURINARY organ tumors
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Language
ISSN
0970-9371
Abstract
Aims: The utility of GATA3 immunohistochemistry (IHC) as an aid to the cytological diagnosis of metastatic breast carcinoma in fine needle aspiration (FNA) specimens was investigated. Materials and Methods: Cell block sections from 111 FNA cases of metastatic malignancy were stained for GATA3, including metastases from 43 breast and 44 nonmammary adenocarcinomas, 19 melanomas, 4 urothelial carcinomas, and 1 thyroid medullary carcinoma. Sites sampled included lymph nodes (87), bone (8), liver (5), lung (6), superficial masses (4), and pelvic mass (1). Results: Ninety-one percent (39/43) of metastatic breast carcinoma cases were positive for GATA3. All estrogen receptor (ER)-positive were also GATA3 positive cases. The majority (9/14; 64%) of ER-negative and 37% (3/8) of triple-negative cases were positive for GATA3. All nonmammary adenocarcinoma cases were negative with the exception of one case of metastatic pancreatic adenocarcinoma. Metastatic melanoma cases were all negative but 75% (3/4) urothelial carcinomas expressed GATA3. Conclusions: GATA3 IHC staining is a useful addition to IHC panels for FNA samples in specific settings such as distinguishing metastatic breast from lung carcinoma or melanoma. [ABSTRACT FROM AUTHOR]