학술논문
Can lipid mediators and free fatty acids guide acute coronary syndrome diagnosis and treatment?
Document Type
Article
Author
Source
Subject
*LIPID metabolism
*TREATMENT of acute coronary syndrome
*INFLAMMATION
*AGE distribution
*ACUTE coronary syndrome
*COMPARATIVE studies
*ATHEROSCLEROSIS
*SEX distribution
*DESCRIPTIVE statistics
*DATA analysis software
*FATTY acids
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Language
ISSN
0007-5027
Abstract
Objective The aim of this study was to investigate fatty acids, lipid mediator levels, and the desaturase index rates on different acute coronary syndrome types and their possible relationship with routine lipid parameters. Methods The study included 81 patients with myocardial infarction (MI), 20 patients with unstable angina pectoris, and 31 healthy people. Fatty acids, CD59, lipoxin A4, 8-isoprostane, serum lipids, albumin, C-reactive protein (CRP), and high sensitive troponin levels were measured in all participants. Results When the fatty acid groups were evaluated as a ratio of albumin, MUFA/albumin and SFA/albumin ratios were significantly higher in the MI group compared to the control group. Although CD59 and lipoxin A4 levels were higher in the control group, there was no significant differences between the groups. When lipoxin A4/CRP and CD59/CRP ratios were evaluated, the results were significantly lower than those in the control group. Conclusion Lipid mediators may be useful in treating atherosclerosis by contributing to the resolution of inflammation. [ABSTRACT FROM AUTHOR]