부산대학교 도서관

Purpose To investigate relationship between the peripapillary retinal vessel diameter and the residual retinal function, measured by mf ERG, in patients with retinitis pigmentosa ( RP). Patients and Methods A cross-sectional study based on 23 patients with RP (43 eyes) and 20 controls (40 eyes) was performed. Retinal vessel diameters were measured using a computer-based program of the retinal vessel analyser ( RVA; IMEDOS Systems UG, Jena, Germany). We evaluated the mean diameter in all four major retinal arterioles (D-A) and venules (D-V) within 1.0-1.5 optic disc diameters from the disc margin. The data were compared with the N1 amplitudes (measured from the baseline to the trough of the first negative wave), with the N1P1 amplitudes (measured from the trough of the first negative wave to the peak of the first positive wave) of the mf ERG overall response and with the mf ERG responses averaged in zones [zone 1 (0°-3°), zone 2 (3°-8°), zone 3 (8°-15°) and zone 4 (15°-24°)]. Results Mean (± SD) D-A and D-V were narrower in patients with RP [84.86 μm (±13.37 μm) and 103.35 μm (±13.65 μm), respectively] when compared to controls [92.81 μm (±11.49 μm) and 117.67 μm (±11.93 μm), respectively; the p-values between groups were p = 0.003 for D-A and p < 0.001 for D-V, linear mixed-effects model]. The RP group revealed clear differences compared to the controls: D-A and D-V became narrower with reduced mf ERG responses. D-V correlated significantly with the overall mf ERG N1 amplitudes (p = 0.013) and with N1P1 amplitudes (p = 0.016). D-V correlated with the mf ERG amplitudes averaged in zones: (zone 2, 3 and 4; p ≤ 0.040) and N1P1 mf ERG amplitudes (zones 1, 2, 3 and 4; p ≤ 0.013). Conclusions Peripapillary retinal vessel diameter is reduced in RP proportionally to functional alterations. [ABSTRACT FROM AUTHOR]