학술논문
Insecticide-Treated Nets and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya.
Document Type
Journal Article
Author
Ochomo, Eric; Chahilu, Mercy; Cook, Jackie; Kinyari, Teresa; Bayoh, Nabie M.; West, Philippa; Kamau, Luna; Osangale, Aggrey; Ombok, Maurice; Njagi, Kiambo; Mathenge, Evan; Muthami, Lawrence; Subramaniam, Krishanthi; Knox, Tessa; Mnavaza, Abraham; Donnelly, Martin James; Kleinschmidt, Immo; Mbogo, Charles
Source
Subject
*MALARIA prevention
*INSECTICIDE resistance
*INSECTICIDE-treated mosquito nets
*MOSQUITO vectors
*PLASMODIUM
*DELTAMETHRIN
*PUBLIC health
*ANIMALS
*DRUG resistance
*INSECTICIDES
*LONGITUDINAL method
*MALARIA
*PROTECTIVE clothing
*PEST control
*PUBLIC health surveillance
*DISEASE incidence
MALARIA transmission
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Language
ISSN
1080-6040
Abstract
Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9-2.5) infections/person-year and 2.8 (95% CI 2.5-3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42-0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35-0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance. [ABSTRACT FROM AUTHOR]