학술논문
Chemobrain: A pilot study exploring the severity and onset of chemotherapy-related cognitive impairment.
Document Type
Article
Author
Source
Subject
*AGE factors in disease
*CANCER chemotherapy
*CANCER patients
*CHI-squared test
*COGNITION
*COGNITIVE testing
*COGNITION disorders
*CONFIDENCE intervals
*EXPERIMENTAL design
*LONGITUDINAL method
*SCIENTIFIC observation
*PSYCHOLOGICAL tests
*REGRESSION analysis
*RESEARCH funding
*T-test (Statistics)
*PILOT projects
*DISABILITIES
*CONTINUING education units
*DATA analysis software
*ELECTRONIC health records
*DESCRIPTIVE statistics
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Language
ISSN
1092-1095
Abstract
BACKGROUND: Chemotherapy-related cognitive impairment refers to a cluster of symptoms commonly referred to as "chemobrain". To date, nursing literature on the progression of and tools used to evaluate chemobrain is limited. OBJECTIVES: The purpose of this pilot study was to explore the onset of chemobrain in patients who recently began chemotherapy treatment, as well as those who have been receiving chemotherapy for an extended period of time. METHODS: This prospective, nonrandomized, observational pilot feasibility study used the General Practitioner Assessment of Cognition and the Trail Making Test Parts A and B to examine chemotherapy-related cognitive impairment symptoms in patients undergoing chemotherapy treatment. FINDINGS: Paired t tests showed a significant difference in scores on the Trail Making Test Part A from baseline to eight months (p < 0.05) and in scores on the Trail Making Test Part B from four to eight months (p < 0.05). The mixed results suggest that the Trail Making Test Parts A and B may not be effective for testing chemotherapy-related cognitive impairment in patients. [ABSTRACT FROM AUTHOR]