부산대학교 도서관

Background: A Para pneumonic pleural effusion is a collection of exudative pleural fluid due to lung infection, which is pneumonia, defined bypH < 7.2, low pleural fluid glucose, and frank pus in the pleural cavity. The most common cause is bacterial infections. Parapneumonic effusion develops in about one-quarter of all pneumonia patients, and out of these, 15% get infected later, which has both morbidity and mortality. The primary treatment of complicated parapneumonic effusion is drainage of pleural fluid. Studies in the past with streptokinase have shown mixed results. Material and Method: The study was conducted on patients with complicated parapneumonic effusion admitted to the chest department of SNMC (Sarojini Naidu Medical College) Agra from January 2014 - to December 2014. Based on drug administration, patients were divided into Group A normal saline) and Group B (streptokinase).Group A patients got 250,000 IU of dissolved STK (Streptokinase) through a chest tube twice a day for five days, while Group B patients received normal saline through a chest tube twice a day for five days. Results: A total of 86 subjects were enrolled in our study. Of these, four could not be followed up. Only 82 completed the study. 21 out of 41 patients (51.21%) were cured in the regular saline group, and 31 out of 41 patients (75.60%) get cured in the streptokinase group. Conclusion: Our study concluded that streptokinase infusion through chest drain in complicated parapneumonic effusion should be tried before sending patients to surgical treatment. It is safe and cost-effective. [ABSTRACT FROM AUTHOR]