부산대학교 도서관

Objective: Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear. Methods: The distribution and determinants of osteopontin were studied in a randomized cohort of 1,817 young adults (aged 30-45 years) without clinical symptoms of atherosclerosis. Results: The mean ± SD osteopontin concentration was 60.7 ± 15.6 μg/mL in men and 51.7 ± 16.0 μg/mL in women. In multivariable models the correlates of osteopontin explained 6.9% (Model R2) of the total variation in osteopontin in men, including CRP (β == 3.02, p < 0.0001), SHBG (β == 0.21, p < 0.0001), total cholesterol (β == − 1.78, p == 0.002), age (β == − 0.26, p == 0.02) and alcohol use (β == 0.57, p == 0.04) and of these CRP had the greatest influence (Partial R2 == 2.1%). In women, multivariable correlates of osteopontin included CRP (β == 2.90, p < 0.0001), total cholesterol (β == − 1.99, p == 0.002), insulin (β == − 1.76, p == 0.001), physical activity (β == 0.66, p == 0.03), adiponectin (β == 0.25, p == 0.008) and diastolic blood pressure (β == 0.14, p == 0.003). These five variables explained 6.7% (Model R2) of the total variation in osteopontin, with CRP (Partial R2 == 2.7%) having the greatest influence. Osteopontin was not associated with carotid intima-media thickness, carotid elasticity, brachial endothelial function or the presence of a carotid plaque in either sex. Conclusion: We found no evidence of association between osteopontin levels and early vascular markers of atherosclerosis in asymptomatic young adults, suggesting that osteopontin is not implicated in the preclinical atherosclerotic changes in vascular structure and function. [ABSTRACT FROM AUTHOR]