학술논문
Synthesis and Antimicrobial Activity of 3-Aryland 3-Arylmethyl-Cyclopenta[ c]Pyrazoles and -Cyclopenta[ d ]Isoxazoles.
Document Type
Article
Source
Subject
*ANTI-infective agents
*ACYLATION
*AROMATIC compounds
*HYDRAZINES
*STAPHYLOCOCCUS aureus
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Language
ISSN
0091-150X
Abstract
Acylation of 1-piperidinocyclopentene by aromatic and arylacetic acid chlorides synthesized the corresponding 1,3-diketones that were reacted with hydrazine hydrate to give 3-aryl- and 3-arylmethylcyclopenta[ c]pyrazoles and with hydroxylamine to give the corresponding cyclopenta[ d]isoxazoles. The diketones and heterocyclic compounds prepared from them exhibited weak inhibitory activity against Staphylococcus aureus and Escherichia coli. The starting diketone containing a p-NO group was the most active compound with a minimum inhibitory concentration of 125 μg/mL. [ABSTRACT FROM AUTHOR]