학술논문
Destroy, what destroys you.
Document Type
Article
Author
Source
Subject
*EPSTEIN-Barr virus
*T cells
*THERAPEUTICS
*HODGKIN'S disease
*
*
*
Language
ISSN
2162-4011
Abstract
New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases. [ABSTRACT FROM AUTHOR]