부산대학교 도서관

Simple Summary: Over the last two decades, there has been a major shift in cancer research models. What was once dominated by genetically engineered mice models and fast-growing immortalized cancer cell lines has given way to a number of patient-derived models of cancer (PDMCs) that may be more representative of human disease. However, the complexities of these patient-derived models, both in vitro and in vivo systems, influence both data interpretation and interoperability. To address these challenges, the PDMC Consortium within the National Cancer Institute undertook this review describing the past, present, and future use of PDMCs while providing example vignettes with practical recommendations from the collective experience of the consortium members. For over a century, early researchers sought to study biological organisms in a laboratory setting, leading to the generation of both in vitro and in vivo model systems. Patient-derived models of cancer (PDMCs) have more recently come to the forefront of preclinical cancer models and are even finding their way into clinical practice as part of functional precision medicine programs. The PDMC Consortium, supported by the Division of Cancer Biology in the National Cancer Institute of the National Institutes of Health, seeks to understand the biological principles that govern the various PDMC behaviors, particularly in response to perturbagens, such as cancer therapeutics. Based on collective experience from the consortium groups, we provide insight regarding PDMCs established both in vitro and in vivo, with a focus on practical matters related to developing and maintaining key cancer models through a series of vignettes. Although every model has the potential to offer valuable insights, the choice of the right model should be guided by the research question. However, recognizing the inherent constraints in each model is crucial. Our objective here is to delineate the strengths and limitations of each model as established by individual vignettes. Further advances in PDMCs and the development of novel model systems will enable us to better understand human biology and improve the study of human pathology in the lab. [ABSTRACT FROM AUTHOR]