학술논문
Metabolic relevance for N-hydroxy L-arginine reduction in estrogen-negative breast cancer cells.
Document Type
Article
Author
Source
Subject
*ARGININE
*BREAST cancer treatment
*CANCER cells
*BIOMARKERS
*DRUG development
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Language
ISSN
0939-4451
Abstract
We had shown Nw-hydroxy-L-arginine (NOHA) as a promising blood-based biomarker for estrogen-receptor-negative (ER−) breast cancer (BC) that differentiates ER− BC based on grade and molecular phenotype. In this in vitro study, we assessed the metabolic relevance for ER− BC-specific NOHA modulation and correlated them with NOHA regulatory responses. This study aids future NOHA clinical utility in ER− BC diagnosis and therapy management and would prove useful for potential drug discovery and development process. [ABSTRACT FROM AUTHOR]