학술논문
Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.
Document Type
Article
Author
Source
Subject
*AUTISM risk factors
*BIOMARKERS
*GLUTATHIONE
*CONFIDENCE intervals
*REGRESSION analysis
*OXIDATIVE stress
*RISK assessment
*RESEARCH funding
*DESCRIPTIVE statistics
*PRENATAL care
*TYROSINE
*CHILDREN
*PREGNANCY
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Language
ISSN
0162-3257
Abstract
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. [ABSTRACT FROM AUTHOR]