학술논문
Do complement factor H 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome?
Document Type
Article
Author
Source
Subject
*HEMOLYTIC-uremic syndrome
*ESCHERICHIA coli diseases
*IMMUNOGLOBULIN allotypes
*KIDNEY diseases
*MICROBIAL virulence
*GENETIC mutation
*GENETIC regulation
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Language
ISSN
1744-3121
Abstract
Summary Typical haemolytic uraemic syndrome (HUS) is mainly caused by infections with enterohaemorrhagic Escherichia coli, whereas in atypical, nonbacteria-associated HUS, complement plays a dominant role. Recently, complement has also been shown to be involved in typical HUS. In this study, mostly weakly significant associations with homozygosities of complement allotype C7 M and inversely with factor H 402H were found, suggesting that 402Y and C7 M allotypes predispose to (typical) haemolytic uraemic syndrome. [ABSTRACT FROM AUTHOR]