부산대학교 도서관

Multicomponent reactions are persuasive approach for developing a chemically diverse set of heterocyclic scaffolds with high yield. Using by conventional as well as microwave , synthesis of a series of new 9-nitro-4-phenyl-2-(pyrimidin-2-yl)-1,2-dihydro-5H-chromeno[4,3-d]pyrimidin-5-one and assessed for their anti-inflammatory activity using the Carrageenan-induced hind paw edema method. Compounds EJ115-J, EJ115-E, & EJ115-A showed significant (p < 0.001) reduction of rat paw edema volume after 1 hr from the administration of the Carrageenan compared to the reference drug, indomethacin. Compounds EJ115-J and EJ115-E showed the highest anti-inflammatory activity, surpassing indomethacin after 4 hr with 65.61% and 60.99% inhibition, respectively. [ABSTRACT FROM AUTHOR]