학술논문
Microsatellite instability-high is rare events in refractory pediatric solid tumors.
Document Type
Article
Author
Source
Subject
*MICROSATELLITE repeats
*IMMUNE checkpoint inhibitors
*CHILD patients
*TUMORS
*
*
*
Language
ISSN
0888-0018
Abstract
Microsatellite instability (MSI)-high status is associated with good responsiveness to immune checkpoint inhibitors. Although MSI-high status has been actively investigated in pediatric brain tumors, studies of other pediatric solid tumors are lacking. Among 334 consecutive pediatric patients with solid tumors, we retrospectively analyzed formalin-fixed paraffin-embedded tumor tissues of 36 of 74 patients (49%) who died of disease. We assessed the MSI status in these tissues using five multiplexed markers. The results revealed that none of the patients had an MSI-high status. These results indicate that MSI-high status is a rare event in pediatric patients with refractory/relapsed solid tumors. Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.1998266 [ABSTRACT FROM AUTHOR]