학술논문
Supramolecular assembly of an Au(III) complex of 2‐(3‐phenyl‐1H‐1,2,4‐triazol‐5‐yl)pyridine: Structure, biological studies and charge transportation.
Document Type
Article
Author
Source
Subject
*PYRIDINE
*KLEBSIELLA pneumoniae
*GRAM-positive bacteria
*ENTEROCOCCUS faecalis
*BACILLUS subtilis
*ANTIBACTERIAL agents
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Language
ISSN
0268-2605
Abstract
An Au(III) complex, [Au(2‐ptp)2]Cl (1) (2‐ptp = 2‐(3‐phenyl‐1H‐1,2,4‐triazol‐5‐yl)pyridine), has been characterized by single‐crystal X‐ray diffraction technique and other spectroscopic data. Presence of different noncovalent interactions leads to the formation of 3D supramolecular structure. The complex 1 exhibits antibacterial activity against Gram‐positive (MIC) (Staphylococcus aureus [240 μg/ml], Bacillus subtilis [645 μg/ml]) and Gram‐negative (Escherichia coli [270 μg/ml], Enterococcus faecalis [820 μg/ml], Klebsiella pneumonia [785 μg/ml]) bacteria. Also, the toxicity of 1 has been checked by MTT assay. The complex shows promising anticancer activity against Vero cells and the CC50 is 405 μg/ml. The complex also shows improved conductivity (Λ) by one order difference on illumination (Λdark, 7.42 × 10−5 Sm−1 and Λillumination, 2.45 × 10−4 Sm−1). [ABSTRACT FROM AUTHOR]