학술논문
N′-Benzylidene-Benzohydrazides as Novel and Selective Tau-PHF Ligands.
Document Type
Article
Author
Source
Subject
*STRUCTURE-activity relationships
*BENZYLIDENE compounds
*LIGANDS (Biochemistry)
*BIOMOLECULES
*BIOMARKERS
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Language
ISSN
1387-2877
Abstract
The structure activity relationship of N′-benzylidene-benzohydrazide (NBB) binding to tau and paired helical filament (PHF) proteins as well as amyloid-β1-42 fibrils indicate differential selectivity for these protein aggregates. The ability of the compounds to stain neurofibrillary tangles and senile plaques isolated from human AD brain was investigated histochemically. These studies resulted in several tau-PHF and amyloid-β1-42 fibril selective ligands respectively. Supported by these results, we rationalized a model for the design of selective ligands for tau, PHF, and amyloid-β1-42 fibrils. [ABSTRACT FROM AUTHOR]