학술논문
Vitamin D levels in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Document Type
Journal Article
Author
Carluccio, Maria; Di Donato, Ilaria; Pescini, Francesca; Battaglini, Marco; Bianchi, Silvia; Valenti, Raffaella; Nannucci, Serena; Franci, Beatrice; Stromillo, Maria; De Stefano, Nicola; Inzitari, Domenico; Pantoni, Leonardo; Nuti, Ranuccio; Federico, Antonio; Gonnelli, Stefano; Dotti, Maria; Carluccio, Maria Alessandra; Stromillo, Maria Laura; Dotti, Maria Teresa
Source
Subject
*PHYSIOLOGICAL effects of vitamin D
*CEREBRAL small vessel diseases
*BRAIN diseases
*CEREBROVASCULAR disease
*VASCULAR dementia
*DEMENTIA
*VITAMIN D metabolism
*BRAIN
*LONGITUDINAL method
*MAGNETIC resonance imaging
*CADASIL syndrome
*DIAGNOSIS
BRAIN metabolism
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Language
ISSN
1590-1874
Abstract
Besides its well known function on bone metabolism, vitamin D role in cerebrovascular pathologies including cerebral small vessel disease has been confirmed by recent meta-analysis. In this study, we measured vitamin D levels in 56 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients (mean age 49.9) with no or minimal disability (modified Ranking Score, mRS ≤2) and in 56 age, sex and seasonality matched healthy controls. History of ischemic events was recorded and cognitive functions were assessed using the Mini-Mental State Examination. White matter hyperintensities on brain T2-weighted magnetic resonance images were classified according to a modified Fazekas scale. Comparison of vitamin D levels between patients and controls showed significant lower values (p < 0.05) in no-to-mild CADASIL patients and a higher number of subjects with severe deficiency [25(OH)D <10 ng/ml]. Vitamin D levels did not correlate with vascular risk factors, clinical data or Fazekas score. The role of vitamin D is worth to be further explored in prospective studies. [ABSTRACT FROM AUTHOR]