부산대학교 도서관

OBJECTIVE: To determine the effects of weight variability on cardiovascular risk factors. DESIGN: Longitudinal study (followed from 1990 to 1998). SUBJECTS: Five-hundred and eighty nonsmoking Japanese male office workers aged 25-49 y. MEASUREMENTS: Baseline levels and slopes of seven selected cardiovascular risk factors (systolic and diastolic blood pressure, total and high-density lipoprotein cholesterol, triglyceride, uric acid and hemoglobin A[sub 1c]) and body mass index (BMI) variables (baseline BMI, BMl-slope, the root mean square error (BMI-RMSE), and the BMl-slope×BMlRMSE interaction). RESULTS: From the multiple regression analyses, the slopes of the six cardiovascular risk factors, except hemoglobin A[sub 1c], were most strongly related to the baseline level of each cardiovascular risk factor and BMl-slope. Neither BMIRMSE nor the interaction of BMI-RMSE with BMl-slope was related to these cardiovascular risk factor slopes. As for hemoglobin A[sub 1c], BMl-slope and the interaction of BMI-RMSE with BMl-slope were not significantly related to hemoglobin A[sub 1c] slope but baseline BMI and BMI-RMSE were. Furthermore, hemoglobin A[sub 1c] slope values were significantly higher among those who cycled at >4.0 kg than among those who did not. CONCLUSION: The only cardiovascular risk factor associated with BMI variability was hemoglobin A[sub 1c]. Weight variability had less or little impact on cardiovascular risk factors compared with BMl-slope and baseline BMI. [ABSTRACT FROM AUTHOR]