학술논문
Galectin 3 complements BNP in risk stratification in acute heart failure.
Document Type
Article
Author
Source
Subject
*GALECTINS
*LECTINS
*HEART failure
*HEART diseases
*FIBROSIS
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*
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Language
ISSN
1354-750X
Abstract
Background: Galectin 3 (G3) is a mediator of fibrosis and remodeling in heart failure. Methods: Patients diagnosed with and treated for Acute Heart Failure Syndromes were prospectively enrolled in the Decision Making in Acute Decompensated Heart Failure multicenter trial. Results: Patients with a higher G3 had a history of renal disease, a lower heart rate and acute kidney injury. They also tended to have a history of HF and 30-day adverse events compared with B-type natriuretic peptide. Conclusion: In Acute Heart Failure Syndromes, G3 levels do not provide prognostic value, but when used complementary to B-type natriuretic peptide, G3 is associated with renal dysfunction and may predict 30-day events. [ABSTRACT FROM AUTHOR]