학술논문
Synthesis of Linker Isomers of Quinolin-6-yloxyacetamide Fungicides through Newman-Kwart Rearrangement.
Document Type
Article
Source
Subject
*AROMATIC compound synthesis
*ACETAMIDE derivatives
*PROPANEDIAMINE
*OXYGEN
*SULFUR
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Language
ISSN
0936-5214
Abstract
Novel quinolin-6-ylthioacetamides and quinolin-6-ylpropanamides have been prepared. They are linker isomers of quinolin-6-yloxyacetamide fungicides in which the oxygen atom of the O,S-acetal in the original lead structures has been replaced by either a sulfur atom or a methylene bridge. The Newman-Kwart rearrangement proved to be highly useful for the concise synthesis of the quinolin-6-ylthioacetamides from available quinolinol building blocks. [ABSTRACT FROM AUTHOR]