학술논문
Crystal Structure and Intermolecular Energy for Some Nandrolone Esters.
Document Type
Article
Author
Source
Subject
*CRYSTAL structure
*NANDROLONE
*INTERMOLECULAR interactions
*ESTERS
*SURFACE analysis
*ANDROGENS
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Language
ISSN
1420-3049
Abstract
Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic–androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld surfaces analysis accompanied by evaluation of crystal energies and intermolecular interactions computation. Also, the solubility of the esters was investigated from a pharmaceutical perspective. [ABSTRACT FROM AUTHOR]