학술논문
Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?
Document Type
Article
Author
Source
Subject
*ALGORITHMS
*FAT content of food
*IRRITABLE colon
*LONGITUDINAL method
*LOW-fat diet
*MALABSORPTION syndromes
*RADIONUCLIDE imaging
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*DATA analysis
*TREATMENT effectiveness
*PRE-tests & post-tests
*DATA analysis software
*DESCRIPTIVE statistics
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Language
ISSN
1470-2118
Abstract
This study evaluates the efficacy of low-fat dietary interventions in the management of gastrointestinal (GI) symptoms due to bile acid malabsorption. In total, 40 patients with GI symptoms and a 7-day 75selenium homocholic acid taurine (SeHCAT) scan result of <20%, were prospectively recruited and then advised regarding a low-fat dietary intervention. Before and after dietary intervention, patients rated their GI symptoms using a 10-point numerical scale, and recorded their intake in 7-day dietary diaries. After dietary intervention, the median scores for all GI symptoms decreased, with a significant reduction for urgency, bloating, lack of control, bowel frequency (p≤0.01). Mean dietary fat intake reduced to 42 g fat after intervention (p≤0.01). Low-fat dietary interventions in patients with a SeHCAT scan result of <20% leads to clinically important improvement in GI symptoms and should be widely used. [ABSTRACT FROM AUTHOR]