학술논문

Mendelian genetics of male infertility.
Document Type
Article
Source
Annals of the New York Academy of Sciences. Dec2010, Vol. 1214 Issue 1, pE1-E17. 17p. 1 Diagram, 5 Charts.
Subject
Language
ISSN
0077-8923
Abstract
Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive techniques (ART), we are now able to overcome sterility and bypass nature's protective mechanisms that developed through evolution to prevent fertilization by defective or deficient sperm. [ABSTRACT FROM AUTHOR]