학술논문
Vitamin A Positively Correlates with Secretory Immunoglobulin A: A Cross-Sectional Study in Omicron COVID-19 Outpatients.
Document Type
Article
Author
Turrubiates-Hernández, Francisco Javier; García-Arellano, Samuel; Herrera-Jiménez, Laura Elena; González-Estevez, Guillermo; Márquez-Sandoval, Fabiola; Padilla-Bórquez, Diana Lourdes; Ceja-Gálvez, Hazael Ramiro; Vega-Magaña, Natali; Nicoletti, Ferdinando; Muñoz-Ríos, Guillermina; Muñoz-Valle, José Francisco
Source
Subject
*IMMUNOGLOBULIN A
*SARS-CoV-2 Omicron variant
*VITAMIN A
*RETINOL-binding proteins
*FOOD consumption
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Language
ISSN
2077-0383
Abstract
Background: Respiratory tract infections remain among the leading causes of mortality worldwide. The COVID-19 pandemic has highlighted the importance of mucosal immunity in defending against infectious agents. Vitamin A is known to influence the production of secretory immunoglobulin A (SIgA) predominantly in the gut, where it is a critical component of the first line of defense on mucosal surfaces. Methods: This cross-sectional study, conducted 14 days post-positive COVID-19 diagnosis, aimed to determine the relationship between the nutritional status of vitamin A and SIgA levels in COVID-19 outpatients. Serum and saliva samples were collected. Vitamin A nutritional status was determined based on the assessment of dietary intake and the analysis of retinol-binding protein 4 (RBP4). SIgA levels were analyzed from salivary samples. In addition, serum antibodies were analyzed. Results: Dietary vitamin A intake and RBP4 levels positively correlated with SIgA. Patients with higher vitamin A intake showed higher SIgA/IgG1 and SIgA/IgG3 ratios, while those with higher RBP4 levels showed higher SIgA/IgM, SIgA/IgG1, and SIgA/IgG2 ratios. Conclusions: These findings underscore a significant correlation between vitamin A nutritional status and SIgA levels in COVID-19 outpatients, which may suggest the potential importance of maintaining optimal vitamin A levels for the prevention of viral infections. [ABSTRACT FROM AUTHOR]