학술논문
Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn -2, and13 C–14 N and13 C–31 P Couplings in Their13 C NMR Spectra.
Document Type
Article
Author
Source
Subject
*SILICA gel
*ACIDS
*LECITHIN
*
*
Language
ISSN
0936-5214
Abstract
Although 4-Me2 NC5 H4 N (DMAP) is a standard base for esterification of (2-Me-6-NO2-C6 H3 CO)2 O (MNBA), N -methylimidazole (NMI) was examined for the condensation of acids with 1-stearoyl-lysophosphatidylcholine because of the non-tailing nature of NMI on silica gel. Acids tested were EPA, α-linolenic acid, TBS ethers of 18-HEPE and ricinoleic acid, acid-labile epoxy acids, and a phenyldiynyl acid. The condensation proceeded well with these acids, and chromatographic separation of resulting phosphatidylcholines and remaining NMI was easily performed. During the characterization of the products by13 C NMR spectroscopy,13 C–14 N and13 C–31 P couplings were observed. [ABSTRACT FROM AUTHOR]