학술논문
A short peptide that preferentially binds c-MYC G-quadruplex DNA.
Document Type
Article
Author
Source
Subject
*DNA
*HUMAN genome
*DNA structure
*CRYSTAL structure
*
*
*
Language
ISSN
1359-7345
Abstract
G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested. [ABSTRACT FROM AUTHOR]