학술논문
Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4- g ]isoquinolines.
Document Type
Article
Author
Source
Subject
*ISOQUINOLINE
*ALKYL group
*KINASE inhibitors
*BROMINE
*
*
*
Language
ISSN
1420-3049
Abstract
A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was detrimental to Haspin inhibition, while the introduction of an alkyl group at the 4-position led to a modification of the kinase inhibition profiles. Altogether, the results obtained demonstrated that new pyrazolo[3,4-g]isoquinolines represent a novel family of kinase inhibitors with various selectivity profiles. [ABSTRACT FROM AUTHOR]