학술논문
Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France.
Document Type
Article
Author
Pérot, Philippe; Fourgeaud, Jacques; Rouzaud, Claire; Regnault, Béatrice; Da Rocha, Nicolas; Fontaine, Hélène; Le Pavec, Jérôme; Dolidon, Samuel; Garzaro, Margaux; Chrétien, Delphine; Morcrette, Guillaume; Jo Molina, Thierry; Ferroni, Agnès; Leruez-Ville, Marianne; Lortholary, Olivier; Jamet, Anne; Eloit, Marc
Source
Subject
*CIRCOVIRUS diseases
*CHRONIC active hepatitis
*VIRAL genomes
*VIRAL replication
*LIVER enzymes
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Language
ISSN
1080-6040
Abstract
In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017-2019, then became detectable at low levels in September 2020 and peaked at very high titers (1010 genome copies/mL) in January 2022. In March 2022, we found >108 genome copies/g or mL in the liver and blood, concomitant with hepatic cytolysis. We detected HCirV-1 transcripts in 2% of hepatocytes, demonstrating viral replication and supporting the role of HCirV-1 in liver damage. [ABSTRACT FROM AUTHOR]