부산대학교 도서관

The irreversible bone resorption accompanied by atrophy and reconstruction of soft tissue around the tooth loss site is still a challenging problem for implant therapy. The present study describes biphasic materials composed of fish-collagen/poly (lactide-co-glycolide) electrospun membranes and nano-hydroxyapatite/poly (lactide-co-glycolide) scaffolds for the regeneration of oral hard and soft tissues. Meanwhile, the injectable platelet-rich fibrin (i-PRF) from autologous blood was prepared and characterized for combined application. The in-vitro experimental results confirmed that the fabricated biphasic material had high cytocompatibility and could enhance the in-vitro osteogenic differentiation. Moreover, an animal model of oral simultaneous tissue defects in the palate of rabbits was established to evaluate the repair efficiency of the biphasic materials combined with i-PRF. It was found to have good biocompatibility and regeneration activity in vivo after the implantation into the defects areas in rabbits, and the combination of i-PRF with biphasic materials was more favored for oral simultaneous tissue regeneration. Conclusively, this research suggests that the fabricated biphasic materials combined with i-PRF may have a promising prospect for the simultaneous regeneration of oral soft and hard tissues. [ABSTRACT FROM AUTHOR]