부산대학교 도서관

Red wine intake is associated with a low risk of cardiovascular disease. This effect has been partly attributed to the action of polyphenolic compounds, which decrease the oxidation of plasma low density lipoproteins. Moreover, nitric oxide (...NO) is a vasodilator and polyphenolic compounds induce endothelium-dependent vasorelaxation in vitro. 2 Here we studied whether a diet rich in dealcoholated red wine (DRW) increases acetylcholineinduced vasorelaxation and whether ingestion of DRW-, quercetin- or catechin-rich diets modifies the ...NO-cyclic guanosine-3',5'-monophosphate (cyclic GMP) pathway and superoxide anion (O[sub 2, sup -]) release in aorta in a resting state in rats fed semi-purified diets containing either 35% (v w[sup -1]) DRW, 0.3% (w w[sup -1]) quercetin or 0.3% (w w[sup -1]) catechin for 10 days. 3 ...NO-mediated vasorelaxation induced by acetylcholine was greater in rats fed the DRW-rich diet than in those that received the control diet. 4 Expression of endothelial ...NO synthase (eNOS) was similar in the four dietary groups. The aortic rings of rats fed either the DRW-, quercetin-, or catechin-rich diets showed higher NOS activity, ...NO production and cyclic GMP content than those of rats fed the control diet. No changes were observed in O[sub 2, sup -] production. 5 In summary, diets rich in either DRW, quercetin or catechin induced endothelium-dependent vasorelaxation in rat aorta in a resting state through the enhancement of ...NO production, without modifying O[sub 2, sup -] generation, thus the bioavailability of ...NO was increased. The increase in the ...NOcyclic GMP pathway explains the beneficial effect of flavonoids at vascular level. [ABSTRACT FROM AUTHOR]