학술논문
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.
Document Type
Article
Author
Source
Subject
*G proteins
*CHROMOSOME abnormalities
*SACCHAROMYCES cerevisiae
*PROTEINS
*YEAST
*FRAGILE X syndrome
*DNA replication
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Language
ISSN
1545-9993
Abstract
Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint. [ABSTRACT FROM AUTHOR]