학술논문
Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus).
Document Type
Article
Author
Nguyen, Elizabeth Dong; Fard, Vahid Nikoonejad; Kim, Bernard Y.; Collins, Sarah; Galey, Miranda; Nelson, Branden R.; Wakenight, Paul; Gable, Simone M.; McKenna, Aaron; Bammler, Theo K.; MacDonald, Jim; Okamura, Daryl M.; Shendure, Jay; Beier, David R.; Ramirez, Jan Marino; Majesky, Mark W.; Millen, Kathleen J.; Tollis, Marc; Miller, Danny E.
Source
Subject
*MICE
*RNA sequencing
*SKIN injuries
*REGENERATION (Biology)
*SOFT tissue injuries
*
*
*
*
Language
ISSN
2160-1836
Abstract
There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from 4 different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism. [ABSTRACT FROM AUTHOR]