부산대학교 도서관

Glucocorticoids are the cornerstone of immunosuppressive and anti-inflammatory therapy in humans, yet the mechanisms of glucocorticoid immunoregulation and toxicity remain unclear. The response to glucocorticoids is highly cell type-dependent, so translating results from different experimental systems into a better understanding of glucocorticoid effects in humans would benefit from rapid access to high-quality data on the response to glucocorticoids by different cell types. We i ntroduce GCgx, a web application that allows investigators to quickly visualize changes in transcript abundance in response to glucocorticoids in a variety of cells and specie s. The tool is designed to grow by the addition of datasets based on input from the user c ommunity. GCgx is implemented in R and HTML and packaged as a Docker image. The t ool and its source code are publicly available. [ABSTRACT FROM AUTHOR]