학술논문
Cord blood plasma reference intervals for potential sepsis markers: Pro-adrenomedullin, pro-endothelin, and pro-atrial natriuretic peptide
Document Type
Article
Source
Subject
*SEPSIS
*CORD blood
*BLOOD plasma
*BIOMARKERS
*ADRENOMEDULLIN
*ATRIAL natriuretic peptides
*NEONATAL diseases
*DISEASE risk factors
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Language
ISSN
0009-9120
Abstract
Abstract: Objectives: To establish reference values in cord blood of the following new sepsis markers: pro-adrenomedullin (MR-proADM), pro-endothelin (CT-proET-1), and pro-atrial natriuretic peptide (MR-proANP). Methods: MR-proADM, CT-proET-1, MR-proANP, and procalcitonin (PCT) were measured in cord blood of newborn infants by Time Resolved Amplified Cryptate Emission (TRACE) technology. The inclusion criteria in the control group (n =194) was the absence of any clinical sign or risk factor of sepsis. A group of 73 newborn infants presenting with risk factors of sepsis at delivery was also studied. Results: The median values (reference interval) of CT-proET-1, MR-pro-ADM, and MR-proANP measured in cord blood plasma were 72pmol/L (39–115), 0.84nmol/L (0.5–1.38), and 163pmol/L (76–389), respectively. The PCT reference interval was not significantly different from that previously described in cord blood serum. Conclusions: The reference intervals established will serve as a starting point for further clinical investigations aimed to elucidate the potential prognostic/diagnostic value of these markers in neonatal sepsis management. [Copyright &y& Elsevier]