학술논문
Maternal Carriage in Late-Onset Group B Streptococcus Disease, Italy.
Document Type
Journal Article
Author
Berardi, Alberto; Spada, Caterina; Creti, Roberta; Auriti, Cinzia; Gambini, Lucia; Rizzo, Vittoria; Capretti, Mariagrazia; Laforgia, Nicola; Papa, Irene; Tarocco, Anna; Lanzoni, Angela; Biasucci, Giacomo; Piccinini, Giancarlo; Nardella, Giovanna; Latorre, Giuseppe; Merazzi, Daniele; Travan, Laura; Letizia, Maria; Reggiani, Bacchi; Baroni, Lorenza
Source
Subject
Language
ISSN
1080-6040
Abstract
We retrospectively investigated mother-to-infant transmission of group B Streptococcus (GBS) in 98 cases of lateonset disease reported during 2007-2018 by a network in Italy. Mothers with full assessment of vaginal/rectal carriage tested at prenatal screening (APS) and at time of late onset (ATLO) were included. Thirty-three mothers (33.7%) were never GBS colonized; 65 (66.3%) were vaginal/rectal colonized, of which 36 (36.7%) were persistently colonized. Mothers with vaginal/rectal colonization ATLO had high rates of GBS bacteriuria (33.9%) and positive breast milk culture (27.5%). GBS strains from mother-infant pairs were serotype III and possessed the surface protein antigen Rib. All but 1 strain belonged to clonal complex 17. GBS strains from 4 mother-infant pairs were indistinguishable through pulsed-field gel electrophoresis. At least two thirds of late-onset cases are transmitted from mothers, who often have vaginal/rectal carriage, positive breast milk culture, or GBS bacteriuria, which suggests heavy maternal colonization. [ABSTRACT FROM AUTHOR]