학술논문
The NPM1 Mutation Type Has No Impact on Survival in Cytogenetically Normal AML.
Document Type
Article
Author
Source
Subject
*GENETIC mutation
*ACUTE myeloid leukemia
*DISEASE remission
*PROGRESSION-free survival
*CYTOGENETICS
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Language
ISSN
1932-6203
Abstract
NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML. [ABSTRACT FROM AUTHOR]