학술논문
Assessment of Expression of Genes Coding GABA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol.
Document Type
Article
Author
Source
Subject
*GENE expression in mammals
*GABA receptors
*ETHANOL
*ALCOHOL poisoning
*LABORATORY rats
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Language
ISSN
0007-4888
Abstract
Expression of genes encoding the individual subunits of ionotropic GABA receptor was assessed after acute and chronic intoxication of rats with ethanol. The chronic 1-month-long exposure to ethanol signifi cantly decreased (by 38%) expression of Gabrb1 gene in the hippocampus. Acute exposure to ethanol elevated expression of genes Gabrb1 (by 1.7 times), Gabra1 (by 3.8 times), and Gabra4 (by 6.5 times), although it diminished expression of Gabra2 gene by 1.4 times. In preliminarily alcoholized rats, acute intoxication with ethanol enhanced expression of genes Gabrb1 and Gabra5 by 1.7 and 8.7 times, respectively. There was neither acute nor chronic effect of ethanol on expression of gene Gabra3. [ABSTRACT FROM AUTHOR]