학술논문
The Role of Glucose Transporter 1 in Drug Delivery: Transporter, Receptor and/or Signaling Component.
Document Type
Article
Author
Source
Subject
*GLUCOSE transporters
*ENDOCYTOSIS
*BRAIN tumors
*CELL membranes
*ENDOTHELIAL cells
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Language
ISSN
2150-5578
Abstract
The targeting of cell surface molecules is a promising strategy in drug delivery. Glucose modifiednanocarrier interacts with glucose transporter 1 (GLUT1) as a target molecule and increases nanocarrier-drug internalization to cancer and brain endothelial cells. The mechanism by which GLUT1 promotes nanocarrier internalization remains unclear. Herein, we propose that the interaction of GLUT1 and nanocarrier absorbs and traps the nanocarrier and simultaneously activates cell signaling pathways that is responsible for activation of the endocytosis system. [ABSTRACT FROM AUTHOR]