학술논문
Clearance of dying cells and autoimmunity.
Document Type
Article
Source
Subject
*PHAGOCYTOSIS
*CELLS
*AUTOIMMUNITY
*INFLAMMATION
*HOMEOSTASIS
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*
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Language
ISSN
0891-6934
Abstract
Phagocytic clearance of apoptotic cells is an important physiologic homeostatic mechanism that is associated with non-inflammatory or anti-inflammatory sequalae. Disruption of the process of apoptotic cell clearance may contribute to development of a number of inflammatory and autoimmune diseases. In this review, we summarize the molecular pathways that have been suggested to account for phagocytic clearance of apoptotic cells. We discuss potential mechanisms for regulation of phagocytosis and the implications for development of autoimmunity. [ABSTRACT FROM AUTHOR]