학술논문
Green methodologies for the synthesis of 2-aminothiophene.
Document Type
Article
Source
Subject
*SUSTAINABLE chemistry
*ENERGY consumption
*
Language
ISSN
1610-3653
Abstract
Pollution and the rising energy demand have prompted the design of new synthetic reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2-aminothiophene have recently focused interest because 2-aminothiophene is a unique 5-membered S-heterocycle and a pharmacophore providing antiprotozoal, antiproliferative, antiviral, antibacterial or antifungal properties. Here, we review new synthetic routes to 2-aminothiophenes, including multicomponent reactions, homogeneously- or heterogeneously-catalyzed reactions, with focus on green pathways. [ABSTRACT FROM AUTHOR]