학술논문
Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury.
Document Type
Article
Author
Source
Subject
*TRANSFORMING growth factors-beta
*ACUTE kidney failure
*CARRIER proteins
*TRANSFORMING growth factors
*MITOCHONDRIA
*RENAL fibrosis
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Language
ISSN
1474-9718
Abstract
Recently, latent transforming growth factor beta binding protein 4 (LTBP4) was implicated in the pathogenesis of renal damage through its modulation of mitochondrial dynamics. The seminal article written by Su et al. entitled "LTBP4 (Latent Transforming Growth Factor Beta Binding Protein 4) Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts" uncovers LTBP4's renoprotective role against acute kidney injury via modulating mitochondrial dynamics. Recently, LTBP4 has emerged as a driver in the mitochondrial‐dependent modulation of age‐related organ pathologies. This article aims to expand our understanding of LTBP4's diverse roles in these diseases in the context of these recent findings. [ABSTRACT FROM AUTHOR]