학술논문
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Document Type
Article
Author
Hecht, Iris; Toporik, Amir; Podojil, Joseph R.; Vaknin, Ilan; Cojocaru, Gady; Oren, Anat; Aizman, Elizabeta; Liang, Spencer C.; Ling Leung; Dicken, Yosef; Novik, Amit; Marbach-Bar, Nadav; Elmesmari, Aziza; Tange, Clare; Gilmour, Ashley; McIntyre, Donna; Kurowska-Stolarska, Mariola; McNamee, Kay; Leitner, Judith; Greenwald, Shirley
Source
Subject
*T cells
*IMMUNOREGULATION
*IMMUNOGLOBULIN receptors
*CYTOKINES
*CHEMOKINES
*AUTOIMMUNITY
*CD28 antigen
*IMMUNOLOGIC diseases
*PHYSIOLOGY
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Language
ISSN
0022-1767
Abstract
The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer. [ABSTRACT FROM AUTHOR]