학술논문
Mycobacterium chelonae-abscessus Complex Associated with Sinopulmonary Disease, Northeastern USA.
Document Type
Article
Author
Simmon, Keith E.; Brown-Elliott, Barbara A.; Ridge, Perry G.; Durtschi, Jacob D.; Mann, Linda Bridge; Slechta, E. Susan; Steigerwalt, Arnold G.; Moser, Benjamin D.; Whitney, Anne M.; Brown, June M.; Voelkerding, Karl V.; McGowan, Karin L.; Reilly, Anne F.; Kirn, Thomas J.; Butler, W. Ray; Edelstein, Paul H.; Wallace Jr., Richard J.; Petti, Cathy A.
Source
Subject
*MYCOBACTERIUM
*LUNG diseases
*IMMUNOCOMPETENT cells
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Language
ISSN
1080-6040
Abstract
Members of the Mycobacterium chelonaeabscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease. [ABSTRACT FROM AUTHOR]