학술논문
Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection.
Document Type
Article
Author
Source
Subject
*INFLUENZA viruses
*INFLUENZA A virus, H3N2 subtype
*MICROBIAL virulence
*PROTEIN expression
*GENETICS of virus diseases
*INFLAMMATION
*GENETICS
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Language
ISSN
1743-422X
Abstract
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical "inflammatory" residues. [ABSTRACT FROM AUTHOR]