학술논문
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.
Document Type
Article
Author
Ahouidi, Ambroise D.; Rodgers, Mary A.; Padane, Abdou; Leye, Nafissatou; Olivo, Ana; Mbow, Moustapha; Mboup, Aminata; Diaw, Papa Alassane; Dia, Aminata; Harris, Barbara; Padane, Yacine Amet Dia; Lo, Gora; Meyer, Todd V.; Diedhiou, Cyrille K.; Diagne, Diabou; Kane, Ndeye Coumba Toure; Cloherty, Gavin; Mboup, Souleymane
Source
Subject
*COVID-19
*SARS-CoV-2
*GENETIC mutation
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Language
ISSN
2045-2322
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages. [ABSTRACT FROM AUTHOR]