학술논문
IgAl and IgA2 immune complexes in primary IgA nephropathy and Henoch-Schönlein nephritis.
Document Type
Article
Author
Source
Subject
*IMMUNE complexes
*KIDNEY diseases
*PATIENTS
*IMMUNE system
*KIDNEY glomerulus diseases
*BLOOD plasma
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Language
ISSN
0009-9104
Abstract
The distribution of IgA subclasses in IgA immune complexes (IgA IC) in sera of patients with primary IgA glomerulonephritis and Henoch-Schönlein purpura nephritis was analysed. High levels of IgA IC containing both IgA I and IgA2 subclasses were present in correlation with the phases of clinical activity. In these nephropathies the finding of IgA subclass distribution in IgA IC similar to that found in secretions may add further support to the hypothesis that IgA IC are of mucosal origin, albeit a primary derangement of the humoral immune system in these patients cannot be disregarded. [ABSTRACT FROM AUTHOR]